This course examines pathophysiological processes integral to the understanding of human health conditions and disorders across the lifespan. Objective and subjective manifestations of common health problems resulting from environmental, genetic, and stress-related maladaptation are assessed and analyzed. Assessment findings, diagnostic testing, and interventions for specific health problems are discussed. The etiology, epidemiology, and pathophysiology of disorders are reviewed within the context of age, gender, lifestyle and sociocultural determinants. Principles of pathophysiology are applied to recognize clinical signs and symptoms consistent with human health conditions. The impact of health promotion and disease prevention on pathophysiological processes across the lifespan are explored.